Charles Keller, Mark S. Hansen, Cheryl M. Coffin and
Mario R. Capecchi, Pax3:Fkhr
interferes with embryonic Pax3 and Pax7 function: implications
for alveolar rhabdomyosarcoma cell of origin, GENES & DEVELOPMENT 18:2608-2613, 2004
Poul H.B. Sorensen,
James C. Lynch, Stephen J. Qualman, Roberto Tirabosco, Jerian F. Lim, Harold
M. Maurer, Julia A. Bridge, William M. Crist, Timothy
J. Triche, Frederic G., PAX3-FKHR and
PAX7-FKHR Gene Fusions Are Prognostic Indicators in Alveolar Rhabdomyosarcoma: A Report From the Children’s Oncology
Group, Journal of Clinical Oncology, Vol 20, Issue 11 (June),
2002: 2672-2679 Â
Introduction
n
Rhabdomyosarcoma
is a cancer made up of cells that normally develop into skeletal muscles of the
body.
n
Alveolar rhabdomyosarcoma
(ARMS), occurs more often in large muscles of the
trunk, arms and legs and typically affects older children or teenagers. This
type is called alveolar because the malignant cells form little hollow spaces,
or alveoli.