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Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarc...

Term Paper Number
898598918
Term Paper Description
Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin (Presentation)
Publish Year
2006
Academy
Tel-Aviv University
Course
Cell Biology
Number Of Sources
2
Price
25 USD
Keywords
Pax3, rhabdomyosarcoma
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Paper Abstract

Charles Keller, Mark S. Hansen, Cheryl M. Coffin and Mario R. Capecchi, Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin, GENES & DEVELOPMENT 18:2608-2613, 2004

Poul H.B. Sorensen, James C. Lynch, Stephen J. Qualman, Roberto Tirabosco, Jerian F. Lim, Harold M. Maurer, Julia A. Bridge, William M. Crist, Timothy J. Triche, Frederic G., PAX3-FKHR and PAX7-FKHR Gene Fusions Are Prognostic Indicators in Alveolar Rhabdomyosarcoma: A Report From the Children’s Oncology Group, Journal of Clinical Oncology, Vol 20, Issue 11 (June), 2002: 2672-2679  

Introduction

n      Rhabdomyosarcoma is a cancer made up of cells that normally develop into skeletal muscles of the body.

n      Alveolar rhabdomyosarcoma (ARMS), occurs more often in large muscles of the trunk, arms and legs and typically affects older children or teenagers. This type is called alveolar because the malignant cells form little hollow spaces, or alveoli.



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